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目的:探讨小儿间质性肺疾病临床表现、影像学改变及病理改变。方法:回顾性分析2006年1月-2013年1月均进行肺组织活检的弥漫性肺疾病患儿24例,对所有患儿肺临床表现、影像学改变及病理改变进行分析。结果:所有患儿均有咳嗽,20例伴有喘憋气促与不同程度的呼吸困难,9例肺部湿罗音;肺部CT显示:18例患儿肺部磨玻璃样改变,5例主要为结节影,2例主要为实变影;病理改变主要为肺间质弥漫性炎症,浆细胞与淋巴细胞浸润,部分患儿出现肉芽肿改变。根据患儿的临床、放射、病理综合考虑有19例符合特发性间质性肺炎,6例为其他类型间质性肺炎。结论:小儿间质性肺炎主要表现为咳嗽、不同程度的呼吸困难,影像学主要变现为磨玻璃影,病理活检为诊断的主要依据。
Objective: To investigate the clinical manifestations, imaging changes and pathological changes of children with interstitial lung disease. Methods: Twenty-four children with diffuse lung disease who underwent lung biopsy from January 2006 to January 2013 were retrospectively analyzed. The clinical manifestations, imaging changes and pathological changes in all children were analyzed. Results: All children had cough, 20 with breathlessness and dyspnea, and 9 cases of pulmonary wet rales. Pulmonary CT showed that the pathological changes of glass in the lungs were observed in 18 cases, and that in the 5 cases For the nodules, 2 cases were mainly solid images; pathological changes mainly diffuse interstitial inflammation, plasma cells and lymphocytes infiltration, granulomas in some children with change. According to children’s clinical, radiological, pathological comprehensive consideration of 19 cases of idiopathic interstitial pneumonia, 6 cases of other types of interstitial pneumonia. CONCLUSIONS: Infantile interstitial pneumonia mainly presents as cough and dyspnea of different degrees. Imaging mainly turns into ground glass, and biopsy is the main basis of diagnosis.