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目的:研究美罗培南延长输注时间和缩短用药间隔在老年重症感染患者中的有效性。方法:入选患者随机分为A、B、C三组。C组为对照组,常规用法,将单次剂量为1 g的美罗培南溶于50 ml生理盐水以微量泵输注治疗,泵注时间为30 min,Q8 h;B组延长输注时间并缩短用药间隔(单次剂量750 mg),输注时间改为60 min,Q6 h;A组仅延长输注时间,输注时间改为60 min,Q8 h。三组用药剂量均为3 g。结果:三组患者中B组有效率显著高于C组,结果差异有统计学意义(P<0.05)。A组相对C组,其无效率显著低于后者,结果差异有统计学意义。结论:美罗培南在保证给药剂量不变的前提下,缩短用药间隔和延长输注时间能提高重症医学科(ICU)老年重症感染患者的感染控制有效率,值得临床推广。
OBJECTIVE: To study the effectiveness of meropenem in prolonging infusion time and shortening the interval of medication in elderly patients with severe infection. Methods: Selected patients were randomly divided into A, B, C three groups. C group as the control group, conventional usage, a single dose of 1 g of Meropenem dissolved in 50 ml of normal saline infusion pump, pump time was 30 min, Q8 h; B group to extend the infusion time and shorten Dose interval (single dose 750 mg), infusion time was changed to 60 min, Q6 h; A group only prolonged infusion time, infusion time was changed to 60 min, Q8 h. Three groups of doses are 3 g. Results: The effective rate of group B in three groups was significantly higher than that in group C, the difference was statistically significant (P <0.05). A group relative to C group, the inefficiency was significantly lower than the latter, the results were statistically significant. Conclusion: Meropenem can improve the infection control efficiency in the elderly patients with severe infectious diseases in intensive care unit (ICU) by shortening the interval and prolonging the infusion time under the premise of keeping the dose unchanged. It is worth to be clinically promoted.