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次级淋巴组织趋化因子(SLC)是体内重要的CC亚族趋化因子成员,能趋化体内多种淋巴细胞到外周组织或器官,与淋巴细胞归巢和DC向淋巴组织的迁移有密切关系。SLC还有抗肿瘤作用,其作用机制包括:募集淋巴细胞和成熟DC;调节细胞因子的分泌;抑制肿瘤血管生成。SLC在肿瘤免疫治疗中具有广泛的应用前景。
Secondary lymphoid tissue chemokines (SLCs) are members of the CC sub-family of chemokines important in the body and can chemotactic to many peripheral lymphocytes to peripheral tissues or organs in vivo with close proximity to lymphocyte homing and DC migration to lymphoid tissues relationship. SLC also anti-tumor effect, its mechanism of action include: recruitment of lymphocytes and mature DC; regulate cytokine secretion; inhibit tumor angiogenesis. SLC in tumor immunotherapy has a wide range of applications.