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应用拉西地平对３０例轻、中型高血压病（ＥＨ）患者治疗４周。观测治疗前后血清超氧化物歧化酶（ＳＯＤ）活力、脂质过氧化物（ＬＰＯ）及空腹胰岛素（Ｉｎｓ）水平。结果显示：（１）ＥＨ患者ＳＯＤ活力较正常人明显下降，ＬＰＯ水平明显升高（Ｐ＜０．０１）；服药后患者ＳＯＤ活力明显回升，ＬＰＯ含量显著降低（Ｐ＜０．０１）；（２）降压作用显著（Ｐ＜０．０１），治疗前后心率无明显变化（Ｐ＞０．０５）；（３）对空腹Ｉｎｓ，血糖，血脂无影响。表明拉西地平降压作用安全、有效，且具有抗氧自由基和保护ＳＯＤ活性的作用。
30 patients with mild to moderate essential hypertension (EH) were treated with lacidipine for 4 weeks. The levels of serum superoxide dismutase (SOD), lipid peroxidation (LPO) and fasting insulin (Ins) were observed before and after treatment. The results showed that: (1) SOD activity in EH patients was significantly lower than that in normal controls and LPO levels were significantly increased (P <0.01); SOD activity in patients with EH was significantly increased and LPO content was significantly decreased (P <0.01); ( (P <0.01). There was no significant change in heart rate before and after treatment (P> 0.05). (3) No effect on fasting insulin, blood glucose and blood lipid. The results show that the antihypertensive effect of lacidipine is safe and effective, and has the function of antioxidant free radicals and protection of SOD activity.