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本文应用心钠素放射免疫分析法初步观测了53例风心病患者心功能不全时血浆心钠素浓度变化,并探讨了与左心房内径的关系。结果发现风心病组血浆心钠素浓度(387.66±28.34pmol/L)较正常对照组(159.94±5.81pmol/L)显著增高(P<0.001);且心衰越严重,血浆心钠素水平升高越明显。但亦有少数(11/53)患者血浆心钠素水平降低。提示血浆心钠素浓度与左心房内径无相关关系(r=0.238,P>0.05).
In this paper, the change of plasma atrial natriuretic peptide (atrial natriuretic peptide) in 53 cases of patients with rheumatic heart disease was observed by atrial natriuretic peptide radioimmunoassay, and the relationship between them and the diameter of the left atrium was also discussed. The results showed that the plasma atrial natriuretic peptide concentration was significantly higher (387.66 ± 28.34pmol / L) than that of the normal control group (159.94 ± 5.81pmol / L) (P <0.001) The more obvious the higher. However, a small number (11/53) of patients with plasma atrial natriuretic peptide levels decreased. Suggesting plasma atrial natriuretic peptide concentration and left atrial diameter has no correlation (r = 0.238, P> 0.05).