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目的 探讨正常眼压性青光眼患者是否存在肾素、血管紧张素水平的异常。设计 前瞻性病例对照研究。研究对象 11例正常眼压性青光眼患者和11名正常人。方法 用放射免疫法测定正常眼压性青光眼患者和正常人的血浆肾素、血管紧张素水平。主要指标 血浆肾素、血管紧张素Ⅱ浓度。结果 正常眼压性青光眼患者和正常人的血浆肾素水平分别为(76 9 0 85±183 2 17)pg/ml/n ,(82 2 0 35±12 4 14 0 ) pg/ml/n ,血管紧张素水平分别为(37 347±10 6 6 9) pg/ml,(2 4 836±10 6 6 5 ) pg/ml,均无明显统计学差异。结论 正常眼压性青光眼患者的血浆肾素、血管紧张素水平无明显异常。
Objective To investigate whether there are abnormalities of renin and angiotensin in normal tension glaucoma patients. Design prospective case-control study. Eleven patients with normal pressure glaucoma and 11 normal subjects were included in the study. Methods The levels of plasma renin and angiotensin in patients with normal tension glaucoma and normal subjects were determined by radioimmunoassay. The main indicators of plasma renin, angiotensin Ⅱ concentration. Results Plasma renin levels in patients with normal tension glaucoma and in normal subjects were (76 9 0 85 ± 183 2 17) pg / ml / n, (82 20 35 ± 12 4 14 0) pg / ml / Angiotensin levels were (37 347 ± 10 6 6 9) pg / ml and (24 836 ± 10 6 6 5) pg / ml, respectively, with no significant difference. Conclusion There is no obvious abnormality of plasma renin and angiotensin in normal tension glaucoma patients.