论文部分内容阅读
目的观察短期胰岛素泵(CSII)与多次皮下注射胰岛素(MSII)强化治疗2型糖尿病的临床疗效与安全性。方法将口服药物治疗血糖控制不佳的2型糖尿病患者63例分为两组,分别给予CSII(n=32)和MSII(n=31)进行短期强化治疗,比较两组治疗后血糖达标时间、空腹血糖(FPG)、餐后2 h血糖(2hPG)、全天血糖波动值、达标时胰岛素用量、治疗2周时胰岛素用量及低血糖情况。结果治疗后CSII组血糖达标时间、FPG、2hPG、全天血糖波动值、达标时胰岛素用量及治疗2周时胰岛素用量均低于MSII组(P<0.05)。CSII组低血糖例次明显少于MSII组(P<0.01)。结论两种胰岛素强化治疗均能有效控制口服药物治疗失败的2型糖尿病患者的血糖,但与MSII对比,CSII治疗控制血糖达标时间更短,达标时胰岛素用量更少,全天血糖波动值更小,低血糖发生率更低,更安全、有效。
Objective To observe the clinical efficacy and safety of short-term insulin pump (CSII) and multiple subcutaneous injections of insulin (MSII) in the treatment of type 2 diabetes mellitus. Methods Sixty-three patients with type 2 diabetes mellitus who underwent poor oral glucose control were divided into two groups: CSII (n = 32) and MSII (n = 31) for short-term intensive treatment. Fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG), blood glucose fluctuations throughout the day, the amount of insulin on target, insulin dosage at 2 weeks, and hypoglycemia. Results After the treatment, the blood glucose level, FPG, 2hPG, whole blood glucose fluctuation, insulin level at the time of treatment and insulin dosage at 2 weeks after treatment in CSII group were lower than those in MSII group (P <0.05). The incidence of hypoglycemia in CSII group was significantly less than that in MSII group (P <0.01). CONCLUSION: Both intensive insulin treatments are effective in controlling blood glucose in type 2 diabetic patients who have failed oral drug treatment. However, compared with MSII, CSII has shorter glycemic control time, less insulin dosage, and lower blood glucose fluctuation throughout the day , Low incidence of hypoglycemia, safer and more effective.