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[目的]探讨海南省恶性淋巴瘤发病的危险因素。[方法]调查156例经病理确诊的恶性淋巴瘤患者和106例同性别、年龄相差上下不超过5岁的健康人,数据采用条件Logistic回归单因素和多因素逐步回归分析。[结果]与恶性淋巴瘤发病相关的因素有:乙型肝炎病毒感染(OR=1.851,95%可信区间1.075￣3.189),慢性炎症持续时间(OR=1.794,95%可信区间1.416￣2.273),经济状况(OR=0.401,95%可信区间0.243￣0.660)。[结论]乙型肝炎病毒感染及慢性炎症持续时间长可增加患恶性淋巴瘤的危险性;而经济状况好则为保护因素。
[Objective] To explore the risk factors of malignant lymphoma in Hainan Province. [Methods] A total of 156 patients with malignant lymphoma diagnosed by pathology and 106 healthy subjects with the same sex and no more than 5 years old were investigated. The data were analyzed by conditional Logistic regression and multivariate stepwise regression analysis. [Results] The factors related to the incidence of malignant lymphoma were hepatitis B virus infection (OR = 1.851, 95% confidence interval 1.075-3.189), duration of chronic inflammation (OR = 1.794, 95% confidence interval 1.416-2.273 ), Economic status (OR = 0.401, 95% confidence interval 0.243 ~ 0.660). [Conclusion] Hepatitis B virus infection and prolonged chronic inflammation can increase the risk of malignant lymphoma; while the economy is good, it is protective factor.