为了研究血管紧张素转化酶2(ACE2)在动脉粥样硬化模型的小鼠中发挥的作用,试验采用8~10周龄APOE基因敲除小鼠,分为普通饮食对照组、高脂饮食模型组、阳性药物对照组(卡托普利给药组)及ACE2激动剂组[血管紧张素转化酶2(ACE2)激动剂重氮氨苯脒乙酰甘氨酸盐(DIZE)给药组],皮下注射给药12周后处死,观察小鼠的肝脏病理学特征,并检测相应血清指标。结果表明:高脂饮食模型组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)比普通饮食对照组显著升高,高密度脂蛋白(HDL)降低,且肝组织脂肪变;而给予卡托普利和DIZE的药物组后都相应降低了TG、TC、LDL含量,提高了HDL含量,并且能够很大程度地减轻肝组织的脂肪病变程度。说明动脉粥样硬化发生的进程中,血脂升高,肝脏也发生了相应病变。而ACE2激动剂DIZE和血管紧张素转化酶抑制剂卡托普利一样,可以降低血脂,改善局部的肝脏病变。 In order to investigate the role of angiotensin-converting enzyme 2 (ACE2) in atherosclerosis model mice, APOE knockout mice aged 8 to 10 weeks were divided into normal diet control group, high fat diet model Group, the positive drug control group (captopril group) and the ACE2 agonist group (ACE2 agonist diazepam acetylglycine (DIZE) group), subcutaneous injection After 12 weeks of administration, sacrifice was performed to observe the liver pathological features of the mice and the corresponding serum indexes were detected. The results showed that triglyceride (TG), total cholesterol (TC) and low density lipoprotein (LDL) in high fat diet group were significantly higher than those in normal diet group, high density lipoprotein (HDL) After administration of captopril and DIZE, the levels of TG, TC and LDL were decreased, the content of HDL was increased, and the degree of fatty lesion in liver tissue was reduced to a great extent. Explain the process of atherosclerosis, elevated blood lipids, the liver also occurred in the corresponding lesions. The ACE2 agonist DIZE and angiotensin-converting enzyme inhibitor captopril, can reduce blood lipids and improve local liver disease.