细胞毒性T淋巴细胞(CTL)能够识别在感染细胞或肿瘤细胞表面表达的与MHC类分子结合的全长8~10个氨基酸的抗原多肽,在控制和消除HBV感染中起核心作用。慢性HBV感染常伴有T细胞低应答和耐受,且树突状细胞(DC)功能不良。而热休克蛋白(hsp)能够诱导T细胞应答和DC成熟。重庆医科大学P Cytotoxic T lymphocytes (CTLs) recognize antigenic peptides of 8 to 10 amino acids in length bound to MHC class molecules expressed on the surface of infected cells or tumor cells and play a central role in controlling and eliminating HBV infection. Chronic HBV infection is often accompanied by low T cell responses and tolerance, and dendritic cells (DCs) are dysfunctional. Heat shock protein (hsp) can induce T cell response and DC maturation. Chongqing Medical University