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目的:探讨血清甲状腺球蛋白抗体（TG-Ab）、甲状腺过氧化物酶抗体（TPO-Ab）与中老年抑郁症患者动脉硬化（AS）的相关性。方法:选取湖州市第三人民医院2018年1月至2019年10月住院治疗的中老年抑郁症患者200例为研究对象，按TG-Ab及TPO-Ab检测结果分为TG-Ab阳性组（第1组）、TPO-Ab阳性组（第2组）、TG-Ab和TPO-Ab双阳性组（第3组）、TG-Ab和TPO-Ab双阴性组（对照组）各50例，检测、比较各组血清甲状腺激素水平、踝臂指数（ABI）、肱-踝动脉脉搏波传导速度（BaPWV）、下肢动脉内-中膜（IMT）增厚及斑块发生率。结果:对照组、第1组、第2组、第3组总甲状腺素（TTn 4）分别为（89.96±2.45）nmol/L、（101.29±3.35）nmol/L、（90.09±2.70）nmol/L、（97.55±2.57）nmol/L，四组差异有统计学意义（n F=3.85，n P < 0.05）。对照组、第1组、第2组、第3组BaPWV分别为（1 327.55±67.78）cm/s、（1 510.36±83.05）cm/s、（1 422.71±71.40）cm/s、（1 533.95±87.01）cm/s，四组差异有统计学意义（ n F=65.12，n P < 0.001）。对照组、第1组、第2组、第3组IMT增厚发生率分别为18%（9/50）、50%（25/50）、32%（16/50）、60%（30/50），斑块形成发生率分别为22%（11/50）、56%（28/50）、40%（20/50）、70%（35/50），四组差异均有统计学意义（χ n 2=21.83、25.77，均n P < 0.001）。logistic多因素回归分析结果显示，年龄（ n OR=0.953）和TG-Ab（n OR=1.116）是中老年抑郁症患者AS的独立危险因素（n P < 0.05）。n 结论:中老年抑郁症患者TG-Ab阳性为并发AS的独立危险因素，TPO-Ab阳性在中老年抑郁症患者AS发生、发展中具有协同作用，TG-Ab及TPO-Ab的检测对中老年抑郁症患者AS的防治具有重要的临床意义。“,”Objective:To investigate the correlation between serum thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) cconcentrations and arteriosclerosis development in middle-aged and older adult patients with depression.Methods:A total of 200 middle-aged and older adult patients with depression who received treatment in the Third People\'s Hospital of Huzhou from January 2018 to October 2019 were included in this study. They were divided into four groups (n n = 50/group) according to TG-Ab and TPO-Ab test results: TG-Ab-positive (group 1), TPO-Ab-positive (group 2), TG-Ab-positive and TPO-Ab-positive (group 3), TG-Ab-negative and TPO-Ab-negative (control group). Serum thyroid hormone level, ankle-brachial pressure index (ABI), brachial-ankle pulse wave velocity, and the incidences of intima-media thickening and plaque formation in the lower extremity arteries were compared between groups.n Results:Total thyroxine concentration in the control group, groups 1, 2 and 3 was (89.96 ± 2.45) nmol/L, (101.29 ± 3.35) nmol/L, (90.09 ± 2.70) nmol/L, (97.55 ± 2.57) nmol/L, respectively. There was a significant difference in total thyroxine concentration between groups (n F = 3.85, n P < 0.05). Brachial-ankle pulse wave velocity in the control group, groups 1, 2, and 3 was (1 327.55 ± 67.78) cm/s, (1 510.36 ± 83.05) cm/s, (1 422.71 ± 71.40) cm/s, (1 533.95 ± 87.01) cm/s, respectively. There was a significant difference in brachial-ankle pulse wave velocity between groups ( n F = 65.12, n P < 0.05). The incidence of intima-media thickening in the control group, groups 1, 2, and 3 was 18% (9/50), 50% (25/50), 32% (16/50), 60% (30/50), respectively. The incidence of plaque formation in the control group, groups 1, 2, and 3 was 22% (11/50), 56% (28/50), 40% (20/50), 70% (35/50), respectively. There were significant differences in intima-media thickening and plaque formation between groups ( n χ2 = 21.83, 25.77, all n P < 0.001). Logistic multivariate regression analysis showed that age ( n OR = 0.953) and TG-Ab (n OR = 1.116) were independent risk factors for developing arteriosclerosis in middle-aged and older adult patients with depression (n P < 0.05).n Conclusion:TG-Ab-positive results are an independent risk factor for developing arteriosclerosis in middle-aged and older adult patients with depression. TPO-Ab-positive results have a synergistic effect on the occurrence and development of arteriosclerosis in middle-aged and older adult patients with depression. Monitoring serum TG-Ab and TPO-Ab concentrations is of great clinical significance for the prevention and treatment of arteriosclerosis in middle-aged and older adult patients with depression.