抗抑郁药用于疼痛综合征始于60年代,其镇痛效果依赖于剂型、剂量及用药时间,但其副作用限制了它的应用。抗抑郁药常被推荐用于治疗慢性疼痛疾病如糖尿病性周围神经痛和带状疱疹后神经痛。在这些适应证中,三环类抗抑郁药疗效最好,其治疗剂量低于治疗抑郁症所需量。 原发性纤维肌痛综合征(FMS)以慢性疼痛、神经内分泌功能失调、与解剖部位相应的再发性触痛 Antidepressants used in pain syndrome began in the 60s, its analgesic effect depends on the dosage form, dosage and medication time, but its side effects limit its application. Antidepressants are often recommended for the treatment of chronic pain disorders such as diabetic peripheral neuropathic pain and post-herpetic neuralgia. Among these indications, tricyclic antidepressants are the most effective and have a lower therapeutic dose than those required for the treatment of depression. Primary fibromyalgia syndrome (FMS) with chronic pain, neuroendocrine dysfunction, and anatomical sites corresponding to recurrent tenderness