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目的了解惠州市手足口病例肠道病毒的感染情况,为制定预防和控制肠道病毒感染策略提供依据。方法采集2010年5月至12月惠州市中心人民医院、惠州市第一人民医院等全市各大医院的998例疑似手足口病患者的疱疹液、脑脊液、咽拭子、粪便等标本,采用实时荧光RT-PCR技术检测样本中的肠道病毒(EV)、肠道病毒71型(EV71)、柯萨奇病毒A组16型(CA16)。结果在检测的682份EV阳性标本中,EV71阳性率偏高,为总数的48.9%,而CA16阳性率较低,为总数的5.71%;在998例疑似手足口病患者中,男性患者居多,占62.12%,女性患者相对较少,占37.88%;0～4岁的儿童是手足口病的高发人群,占所有患者的92.99%;5～7月的夏季为手足口病感染的高峰期,其阳性率占98.9%。结论惠州市2010年5月～12月手足口病的病原体以肠道病毒71型为主,0～4岁的男性儿童是感染肠道病毒的高危人群,5～7月的夏季较为高发。
Objective To understand the infection of enterovirus in hand, foot and mouth disease cases in Huizhou City, and to provide evidence for the prevention and control of enterovirus infection strategy. Methods A total of 998 cases of herpes simplex, cerebrospinal fluid, throat swab and stool were collected from 998 cases of HFMD in Huizhou downtown People’s Hospital, Huizhou First People’s Hospital and other major hospitals from May 2010 to December 2010. Real- Fluorescent RT-PCR was used to detect enterovirus (EV), enterovirus 71 (EV71) and coxsackievirus A group 16 (CA16). Results Among 682 EV positive specimens, the positive rate of EV71 was high, accounting for 48.9% of the total, while the positive rate of CA16 was 5.71%. Among the 998 cases of HFMD, the majority of male patients, Accounting for 62.12%, relatively few female patients, accounting for 37.88%; 0 to 4 years old children are HFMD high incidence population, accounting for 92.99% of all patients; May to July summer peak of hand, foot and mouth disease infection, The positive rate accounted for 98.9%. Conclusion The pathogens of hand, foot and mouth disease in May-December 2010 are mainly enterovirus 71 in Huizhou City. Men aged 0-4 years old are at high risk of enterovirus infection, and are more frequent in summer from May to July.