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目的 :探讨女性哮喘患者月经周期中性激素水平对哮喘发作的影响。方法 :选择女性支气管哮喘患者 40例分为 2组 ,A组为月经期哮喘发作或原有症状加重者 2 0例 ,B组为月经期无哮喘发作或原有症状无变化者 2 0例 ,健康工作人员 2 0例作为对照组C组。各组观察对象均于月经期及经后 1周测定雌二醇 (E2 )、孕酮 (P)、血栓素B2 (TXB2 )、6 酮 前列腺素F1a(6 k PGF1a)。结果 :A组月经期E2 、P最低水平时 ,呼气峰流速 (PEF)波动率 >2 0 % ,经后E2 、P恢复正常时PEF波动率 <2 0 %。A组经期TXB2明显高于经后期 ,经期 6 k PGF1a低于经后期。A组经期E2 、P、TXB2 、6 k PGF1a与B组、C组同期相应指标比较均有明显差异。B组与C组经期及经后 1周PEF波动率均小于 2 0 % ,2组月经期E2 、P、6 k PGF1a相比均无明显差异 (P >0 .0 5 ) ,经期后TXB2 有差异 ,(P <0 0 5 )。结论 :哮喘患者月经前后E2 、P的波动幅度与哮喘发作的程度有明显关系。
Objective: To investigate the effect of menstrual cycle hormones on asthma attacks in female asthma patients. Methods: A total of 40 female patients with bronchial asthma were divided into 2 groups. A group had 20 cases of asthma exacerbation or original symptom during menstruation. Group B had no asthma attack during menstruation or no change of original symptoms. 20 healthy workers as a control group C group. Each group of subjects were measured estradiol (E2), progesterone (TXB2), 6 keto prostaglandin F1a (6 k PGF1a) in the menstrual period and after 1 week. Results: When the E2 and P levels of group A were the lowest, the fluctuation of peak expiratory flow (PEF) was> 20% and the volatility of PEF was less than 20% after E2 and P returned to normal. TXB2 in group A during menstruation was significantly higher than that in the latter group, and the 6-week PGF1a in menstrual period was lower than that in the latter group. A group of menstrual E2, P, TXB2, 6 k PGF1a and B group, C group corresponding indicators were significantly different over the same period. The fluctuation of PEF in group B and group C at one week after menstruation and one week after operation were all less than 20%. There was no significant difference between the two groups in E2, P, 6k PGF1a (P> 0.05) Difference, (P <0 0 5). Conclusion: The fluctuation of E2, P in asthma patients before and after menstruation has a significant relationship with the degree of asthma attack.