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目的探讨β纤维蛋白原基因455G/A多态性与急性心肌梗死发病的关系,寻找急性心肌梗死发病的遗传性危险因素。方法选择急性心肌梗死患者40例,对照组40人,排除有冠心病、缺血性脑卒中及外周血管血栓疾病者。采用碘化钾法提取基因组DNA,采用PCRRFLP技术分析基因型。SPSS软件分析数据。结果急性心肌梗死组中β纤维蛋白原455A等位基因频率显著高于对照组。结论β纤维蛋白原455A等位基因可能是急性心肌梗死发病的遗传性危险因素。
Objective To investigate the relationship between the 455G / A polymorphism of β-fibrinogen gene and the incidence of acute myocardial infarction (AMI) and to find out the genetic risk factors of AMI. Methods Forty patients with acute myocardial infarction and 40 patients in control group were excluded from the study. Patients with coronary heart disease, ischemic stroke and peripheral vascular thrombosis were excluded. Genomic DNA was extracted by potassium iodide method and genotypes were analyzed by PCR-RFLP. SPSS software analyzes the data. Results The frequency of 455A allele of β-fibrinogen in acute myocardial infarction group was significantly higher than that in control group. Conclusion The β fibrinogen 455A allele may be a genetic risk factor for the development of acute myocardial infarction.