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目的:调查目前长沙市乙肝的流行状况,了解长沙市乙肝分型模式及阳性率,为临床乙型肝炎的防治提供可靠的数据参考。方法:选择2016年1月~2016年6月长沙市中心医院体检标本8389例采用电化学发光法检测HBV血清标志物及其含量,并对其进行统计分析。结果:人群中HBsAg携带率为23.04%,单抗-HBs阳性率为28.07%。HBsAg阳性率最高年龄组为31~40岁组(26.69%),最低为0~10岁组(6.26%)。HBsAg阳性率,男性高于女性,单抗-HBs阳性率女性高于男性。8389例样本共检出26种乙肝病毒血清学模式,其中发现6种特殊的乙肝标志物模式。结论:长沙市人群HBsAg携带率较高,乙肝疫苗纳入儿童免疫规划后效果显著,降低了人群HBsAg携带率,特别是10岁以下儿童下降幅度更为明显。本研究中发现的几种特殊的乙肝标志物模式出现的真正原因有待进一步研究。
OBJECTIVE: To investigate the prevalence of hepatitis B in Changsha and to understand the typing patterns and positive rates of hepatitis B in Changsha so as to provide reliable data for the prevention and treatment of hepatitis B. Methods: From January 2016 to June 2016, 8 389 physical examination specimens from Changsha Central Hospital were collected for the detection of HBV serum markers and their contents by electrochemiluminescence. Statistical analysis was performed. Results: The population of HBsAg carrier rate was 23.04%, monoclonal antibody-HBs positive rate was 28.07%. The highest positive rate of HBsAg in the age group was 31 to 40 years (26.69%), the lowest was 0 to 10 years (6.26%). The positive rate of HBsAg in males was higher than that in females, and the positive rate of mab-HBs in females was higher than that in males. A total of 8389 samples were detected 26 kinds of hepatitis B virus serological patterns, which found six kinds of special patterns of hepatitis B markers. Conclusion: The population carrying rate of HBsAg in Changsha is high, and the effect of hepatitis B vaccine in children’s immunization planning is significant, which reduces the carrier rate of HBsAg among the population, especially for children under 10 years of age. The real reasons for the emergence of several specific patterns of hepatitis B markers found in this study are for further study.