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目的 研究EphB4在肺癌组织中的表达和意义。方法 采用免疫组化SP法检测 5 0例肺癌及 2 0例癌旁组织中EphB4的表达水平。结果 EphB4在肺癌组织中的表达水平高于癌旁组织 (P <0 .0 1) ,EphB4的表达与肺癌的分级呈正相关 (P <0 .0 5 ) ,与临床分期及淋巴结转移之间无相关性 (P >0 .0 5 )。结论 EphB4可能在肺癌的发生中起一定的作用
Objective To study the expression and significance of EphB4 in lung cancer. Methods Immunohistochemical SP method was used to detect the expression of EphB4 in 50 cases of lung cancer and 20 cases of paracancerous tissues. Results The expression level of EphB4 in lung cancer tissues was higher than that in adjacent non-cancerous tissues (P <0.01). The expression of EphB4 was positively correlated with the grade of lung cancer (P <0.05), but not between clinical stage and lymph node metastasis Correlation (P> 0.05). Conclusion EphB4 may play a role in the development of lung cancer