多系统器官衰竭(MSOF)是加强监护病房、外科和创伤病房的病人死亡的重要原因之一。这些器官同时或相继发生衰竭,提示有共同的发病机理引起不同器官的功能障碍。许多论著都提到器官灌流量减少是MSOF发病机理的重要一环。许多MSOF病例开始确有低血量休克的阶段,但给动物造成单纯的出血性休克并不能复制出MSOF模型,表明器官低灌流量并非是引起MSOF的决定性因素。 Multisystemic organ failure (MSOF) is one of the major causes of death in intensive care unit, surgical and wounded wards. The failure of these organs simultaneously or sequentially suggests that a common pathogenesis causes dysfunction in different organs. Many studies have mentioned that the reduction of organ perfusion is an important part of the pathogenesis of MSOF. Many MSOF cases start with a stage of hypovolemic shock, but simple hemorrhagic shock in animals does not replicate the MSOF model, indicating that organ perfusion is not a decisive factor in MSOF.