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[目的]观察康复新液联合奥美拉唑治疗非甾体类抗炎药物(NSAID)相关性溃疡的疗效。[方法]对因腹痛伴呕血或黑便入院(除外消化道大出血),经胃镜诊断的99例NSAID相关性消化性溃疡患者,随机分为2组,治疗组50例给予口服康复新液10 ml/次,3次/d,联合奥美拉唑40 mg 2次/d静脉滴注(静滴)治疗;对照组49例选用奥美拉唑40 mg,2次/d静滴,出血停止改口服奥美拉唑20 mg 2次/d。证实幽门螺杆菌(Hp)感染者均加用阿莫西林1.0 g、克拉霉素0.5 g 2次/d,疗程10 d。[结果]治疗组总有效率为94.0%,对照组为69.4%(P<0.05);胃镜疗效总有效率为96.0%,高于对照组的88.8%(P<0.05);Hp根除率为89.19%,与对照组的87.5%无明显差异。[结论]康复新液联合奥美拉唑治疗NSAID相关性溃疡疗效确切,不良反应少。
[Objective] To observe the curative effect of Kangfuxin Solution combined with omeprazole on non-steroidal anti-inflammatory drugs (NSAID) -related ulcer. [Methods] A total of 99 patients with NSAID-related peptic ulcer diagnosed by gastroscopy undergoing abdominal pain with hematemesis or melena admitted to hospital (excluding gastrointestinal hemorrhage) were randomly divided into two groups. The treatment group, 50 patients, were given oral rehabilitation 10 ml / Times, 3 times / d, combined omeprazole 40 mg 2 times / d intravenous infusion (intravenous drip) treatment; control group of 49 patients selected omeprazole 40 mg, 2 times / d intravenous infusion, stop bleeding change Omeprazole 20 mg twice daily / d. Confirmed that Helicobacter pylori (Hp) were infected with amoxicillin 1.0 g, clarithromycin 0.5 g 2 times / d, treatment of 10 d. [Results] The total effective rate was 94.0% in the treatment group and 69.4% in the control group (P <0.05). The total effective rate of gastroscopy was 96.0%, higher than that of the control group (88.8%, P <0.05). The eradication rate of Hp was 89.19 %, 87.5% of the control group no significant difference. [Conclusion] Kangfuxin and omeprazole are effective in treating NSAID-related ulcer with less adverse reactions.