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目的探讨婴幼儿支原体肺炎血清TNF-α和IgE的变化及其临床意义。方法应用酶联免疫吸附法和放射免疫法分别检测60例婴幼儿支原体肺炎患者(其中的34例伴有喘息发作)及35例同期健康体检婴幼儿血清TNF-α和IgE的浓度。结果婴幼儿支原体肺炎患者血清TNF-α和IgE的水平高于健康体检者(P<0.01),且支原体肺炎伴喘息患儿血清TNF-α和IgE的水平高于不伴喘息者(P<0.05)。结论 TNF-α和IgE在婴幼儿支原体肺炎的发生发展过程中起重要作用,也是支原体感染诱发婴幼儿喘息发作的重要因素之一。
Objective To investigate the changes of serum TNF-α and IgE in infants with mycoplasmal pneumonia and its clinical significance. Methods Serum levels of TNF-α and IgE in 60 infants with mycoplasmal pneumonia (34 patients with wheezing episodes) and 35 healthy controls were detected by enzyme-linked immunosorbent assay and radioimmunoassay. Results The levels of serum TNF-α and IgE in infants with mycoplasmal pneumonia were significantly higher than those in healthy subjects (P <0.01). The levels of serum TNF-α and IgE in children with mycoplasma pneumonia and wheezing were higher than those without pneumonia ). Conclusions TNF-α and IgE play an important role in the pathogenesis of mycoplasma pneumonia in infants and young children. It is also one of the important factors in the infantile wheezing induced by mycoplasma infection.