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重组腺相关病毒(rAAV)载体介导的抗体基因治疗药物,可为宿主直接提供中和抗体而使其免受艾滋病毒感染,有望成为艾滋病预防及治疗疫苗的替代品。综述人免疫缺陷病毒(HIV)专属性广谱中和抗体发现过程的文献资料,介绍了rAAV介导的抗HIV抗体基因治疗的试验结果,并对rAAV在艾滋病预防及治疗的研究进展作了分析。
Recombinant adeno-associated virus (rAAV) vector-mediated antibody gene therapy drugs that provide hosts direct neutralizing antibodies against HIV infection are expected to become a substitute for HIV prevention and treatment vaccines. This review summarizes the literature on the discovery of human immunodeficiency virus (HIV) -based broad-spectrum neutralizing antibodies and describes the results of rAAV-mediated gene therapy of anti-HIV antibodies and analyzes the progress of rAAV in the prevention and treatment of AIDS .