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目的考察盐酸胺碘酮注射液在5%葡萄糖注射液、10%果糖注射液及0.9%氯化钠注射液中的配伍稳定性。方法将盐酸胺碘酮注射液按临床常规剂量加入3种输液中,于室温下避光或不避光放置24 h,用HPLC法测定配伍后不同时间点溶液中药物的含量,并观察溶液外观性状、测定pH值。结果盐酸胺碘酮注射液与3种输液配伍后,24 h内无论避光或不避光含量稳定,外观性状、pH均无明显变化。结论盐酸胺碘酮注射液与3种输液的配伍液在24 h内稳定。
Objective To investigate the compatibility of amiodarone hydrochloride injection in 5% dextrose injection, 10% fructose injection and 0.9% sodium chloride injection. Methods The amiodarone hydrochloride injection was added into three kinds of infusions according to the routine clinical dosage. The solution was stored at room temperature for 24 hours in the dark or in the dark. The contents of the drugs in the solution were determined by HPLC at different time points. Traits, determination of pH. Results Amiodarone hydrochloride injection compatibility with the three kinds of infusion, within 24 h regardless of dark or no light stability, appearance, pH, no significant change. Conclusion The compatibility of amiodarone hydrochloride injection and three infusion solutions is stable within 24 h.