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肌萎缩侧索硬化是一种同时累及上、下运动神经元的进行性神经系统变性疾病。肌萎缩侧索硬化患者生存时间短,病死率高,其病因及发病机制不明确,目前尚无有效治疗方法,因此肌萎缩侧索硬化患者的预后评估成为近年来研究的热点。文中从基因水平、颈屈肌肌力、体重指数等方面进行探索,以期寻找影响预后的可靠指标,为提高肌萎缩侧索硬化患者的生活质量、延长生存时间及提供治疗方案寻找新对策。
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease involving both upper and lower motor neurons. Amyotrophic lateral sclerosis patients with short survival time, high mortality, the etiology and pathogenesis is not clear, there is no effective treatment, so patients with amyotrophic lateral sclerosis prognosis evaluation has become a hot spot in recent years. In this paper, we explore the gene level, cervical flexor muscle strength, body mass index and other aspects in order to find a reliable indicator of prognosis, to improve the quality of life of amyotrophic lateral sclerosis patients, to extend the survival time and to provide treatment options to find new strategies.