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目的观察硫酸镁联合拉贝洛尔对重度子痫前期的治疗效果。方法 83例重度子痫前期孕妇,根据就诊日期分为实验组(单数日就诊)43例和对照组(双数日就诊)40例。对照组患者给予硫酸镁常规降压治疗,实验组患者给予硫酸镁联合拉贝洛尔静脉注射治疗,观察两组患者的降压效果。结果治疗后实验组平均动脉压和24 h尿蛋白均显著低于对照组(P<0.05),实验组有效率97.67%显著高于对照组87.50%(P<0.05),实验组不良反应发生率13.95%显著低于对照组30.00%(P<0.05)。结论硫酸镁联合拉贝洛尔对妊娠期高血压的降压效果明显,且不良反应发生率显著低于单纯使用硫酸镁降压,可以在临床中推广应用。
Objective To observe the therapeutic effect of magnesium sulfate combined with labetalol on severe preeclampsia. Methods Eighty - three pregnant women with severe preeclampsia were divided into experimental group (single day treatment) 43 cases and control group (double - day treatment 40 cases) according to the date of treatment. Patients in the control group were given routine antihypertensive treatment with magnesium sulfate. Patients in the experimental group were treated with intravenous injection of magnesium sulfate and labetalol, and the antihypertensive effect was observed in both groups. Results After treatment, mean arterial pressure and 24 h urinary protein in the experimental group were significantly lower than those in the control group (P <0.05), and the effective rate in the experimental group was 97.67%, significantly higher than that in the control group (87.50%, P <0.05). The incidence of adverse reactions in the experimental group 13.95% was significantly lower than the control group 30.00% (P <0.05). Conclusion Magnesium sulphate and labetalol have obvious antihypertensive effect on gestational hypertension, and the incidence of adverse reactions is significantly lower than that of magnesium sulfate alone. It can be widely used in clinic.