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目的研究血清促甲状腺激素(TSH)水平与代谢综合征(MS)及其组分的相关性。方法随机选择对来院体检的540例甲状腺功能正常者采空腹静脉血查血糖(FPG)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(CHOL)、TSH、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平,行糖耐量(OGTT)检测,测身高及体重,计算体重指数,相关回归分析血清TSH水平与血脂水平、高血压、高血糖、代谢综合征的相关性。根据是否患有亚临床甲状腺功能减退分为亚临床甲状腺功能减退组及对照组,比较两组的血脂水平、体重指数及高血压、高血糖、代谢综合征的患病率。结果曲线拟合结果提示所有模型均显示TSH与血脂组分有相关性,偏相关分析提示TSH与CHOL、LDL-C呈显著正相关(P<0.01),与HDL-C显著负相关(P<0.01),Logistic回归分析提示TSH与高血压具有相关性(P<0.05),根据TSH水平分为亚临床甲状腺功能减退组及对照组,组间比较提示亚临床甲状腺功能减退组CHOL、LDL-C水平明显高于对照组(P<0.05),而HDL水平低于对照组(P<0.05),亚临床甲状腺功能减退组的高血压、高血糖、代谢综合征的患病率均高于对照组,但无显著差异(P>0.05)。结论血清TSH水平与血脂组分CHOL、LDL-C呈明显正相关关系,与高血压发病亦相关,与代谢综合征发病关系不密切。
Objective To study the correlation between serum thyrotropin (TSH) levels and metabolic syndrome (MS) and its components. Methods 540 patients with normal thyroid function in our hospital were randomly selected to receive fasting blood glucose (FPG), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C , Total cholesterol (CHOL), TSH, free triiodothyronine (FT3), free thyroxine (FT4), glucose tolerance test (OGTT), height and weight were measured, body mass index TSH levels and lipid levels, hypertension, hyperglycemia, metabolic syndrome. According to whether there is subclinical hypothyroidism into subclinical hypothyroidism group and control group, comparing the two groups of blood lipid levels, body mass index and the prevalence of hypertension, hyperglycemia, metabolic syndrome. Results The curve fitting results showed that all the models showed the correlation between TSH and blood lipid components. Partial correlation analysis indicated that TSH was positively correlated with CHOL and LDL-C (P <0.01), and significantly negatively correlated with HDL-C (P < 0.01). Logistic regression analysis showed that TSH was associated with hypertension (P <0.05). According to TSH level, TSH was divided into subclinical hypothyroidism group and control group. Comparisons between groups showed that CHOL and LDL-C in hypothyroidism group (P <0.05), while the level of HDL was lower than that of the control group (P <0.05). The prevalences of hypertension, hyperglycemia and metabolic syndrome in subclinical hypothyroidism group were significantly higher than those in the control group , But no significant difference (P> 0.05). Conclusions Serum TSH level has a positive correlation with serum lipids CHOL, LDL-C and is also associated with the incidence of hypertension, but not with the incidence of metabolic syndrome.