目的探讨高效价IgG抗体孕妇血清中的IgG抗体亚型与新生儿溶血病的发生及危重程度的关系。方法对血清IgG抗-A(B)效价持续≥512,ABO以外IgG抗体效价持续≥256的孕妇,用德国欧盟公司的亚型试剂盒测定其血清IgG亚型,对其出生后的新生儿脐血进行新生儿溶血系列检测。结果 10例高效价IgG抗体孕妇中5例检出IgG1或IgG3亚型,其生产的新生儿均发生不同程度的高胆红素血症,给予静滴白蛋白,兰光箱治疗,2周后黄疸渐退;5例检出IgG2或IgG4亚型孕妇生产的新生儿未发生高胆红素血症。结论对高效价抗体孕妇进行检测IgG抗体亚型,对检出IgG1或IgG3亚型的给予药物预防性治疗,必要时进行血浆置换;对检出IgG2或IgG4亚型孕妇可以不进行预防性干预治疗,从而有效提高预防性治疗的准确性。 Objective To investigate the relationship between the serum IgG antibody subtype and neonatal hemolytic disease in high titer IgG antibody pregnant women. Methods Serum IgG anti-A (B) titer persisted for ≥512 and IgG antibody titers ≥256 except ABO. Serum IgG subtypes were determined by the subgroup of EU companies in Germany, and their postnatal newborn Umbilical cord blood for newborn hemolysis series testing. Results In 10 pregnant women with high titer of IgG antibody, IgG1 or IgG3 subtype was detected in 5 pregnant women. The neonates were all hyperbilirubinemia with varying degrees of hyperbilirubinemia. After two weeks of intravenous infusion of albumin and blue light box, Jaundice receded; 5 cases detected neonatal IgG2 or IgG4 subtype pregnant women did not occur hyperbilirubinemia. Conclusions High titer anti-body IgG antibodies were detected in pregnant women, prophylactic treatment of IgG1 or IgG3 subtypes was detected, plasma exchange was performed if necessary, and pregnant women without IgG2 or IgG4 subtypes could be treated without prophylactic intervention , So as to effectively improve the accuracy of preventive treatment.