目的:本文以南京市第一医院心血管疾病临床医学研究中心建设的实践经验为模型，为准备建设临床研究中心的机构提供参考与借鉴。方法:中心以临床需求为导向进行顶层设计，从管理机制、研究平台、协同网络、团队建设及国际合作等方面进行系统阐述。结果:中心在临床研究、科技创新、转化推广、规范制定及技术引领等方面取得了显著的成绩；在国际视域基础上，优化学科人才结构、聚焦辐射亚专业临床需求，提升区域诊疗水平。结论:以临床医学中心建设为契机，整合优势资源、提高疾病诊治水平和服务能力，提升中心的国内国际学术影响力，是加快卫生事业发展及深化医疗改革，促成建设健康中国的有效举措。“,”Objective:This article takes the practical experience of the construction of the cardiovascular disease clinical medicine research center in Nanjing First Hospital as an example to provide reference for institutions preparing to build a clinical research center.Methods:The center conducts top-level design based on clinical needs, and this study systematically elaborates the construction of the center from management mechanisms, research platforms, collaborative networks, team building and international cooperation.Results:The center has made remarkable progress in clinical research, scientific and technological innovation, transformation and promotion, standard formulation, and technology leading. On the basis of an international perspective, the level of regional diagnosis and treatment has been improved by optimizing the structure of subject talents, and focusing on the clinical needs of cardiovascular subspecialty.Conclusions:Taking the construction of the clinical medicine center as an opportunity, integrating superior resources, improving the level of disease diagnosis, treatment and service and enhancing international academic influence are effective measures to accelerate the development of health services and deepen medical reforms.