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作者等对12例重型(男7例,女5例,年龄7-18岁,均数11岁)及12例轻型(男女各6例,年龄7-18岁,均数11岁)纯合型镰状细胞病(SCD)患者进行细胞及体液免疫功能研究,并与12例健康对照组(年龄8-17岁,均数11岁)进行比较.重型SCD患者的中性粒细胞迁移试验及白细胞趋化活性(分别为19.1±7及42.9±13.6)与轻型SCD患者(分别为42.3±28及120±44.9)及健康对照组(分别
The author of 12 cases of heavy (7 males and 5 females, aged 7-18 years, mean 11 years) and 12 cases of light (6 males and 6 females, aged 7-18 years, mean 11 years) homozygous Patients with sickle cell disease (SCD) were studied for cellular and humoral immune function and compared with 12 healthy controls (ages 8-17 years, mean, 11 years). Neutrophil migration in patients with severe SCD and leukocyte Chemotactic activities (19.1 ± 7 and 42.9 ± 13.6, respectively) were significantly different from those of patients with mild SCD (42.3 ± 28 and 120 ± 44.9, respectively) and healthy controls