大鼠连续口服Ｌ－甲状腺素４ｍｇ·ｋｇ（－１）×７ｄ可形成心肌肥厚。高甲状腺素状态下，心肌去甲肾上腺素（ＮＥ）增加，交感神经兴奋而使细胞内Ｃａ（２＋）增加，其表现为线粒体Ｃａ（２＋），Ｍｇ（２＋）－ＡＴＰ酶活性增高。大鼠连续３天口服普萘洛尔１０ｍｇ／ｋｇ，维拉帕米５，１０ｍｇ／ｋｇ及卡普托利５ｍｇ／ｋｇ可使肥厚心肌消退，并可降低线粒体钙泵活性。 Continuous oral administration of L-thyroxine 4mg · kg (-1) × 7d can form myocardial hypertrophy. Under the condition of high thyroxine, the activity of norepinephrine (NE) and sympathetic nerve increased and intracellular Ca (2+) increased. The activity of mitochondrial Ca (2 +) and Mg (2 +) - ATPase increased. Rats were treated with propranolol 10 mg / kg, verapamil 5, 10 mg / kg and captopril 5 mg / kg orally for 3 consecutive days to regress hypertrophic myocardium and reduce mitochondrial calcium pump activity.