用肝素处理和预防血栓栓塞已属公认.但有并发症.肝素可引起暂时的血小板减少症.曾认为血小板减少症,是由血小板可逆聚集,移行、和周围扣留所引起.其机制不清,可能与肝素诱发释放二磷酸腺甙(ADP)有关.Weismann等报告,肝素也会引起血栓栓塞.1969年有人提出肝素诱发的血小板减少症可以引起血栓栓塞,并于1973年得到肯定.近10年,许多有关肝素诱发血小板减少症的报告,指出死亡率高,并有发生血栓拴塞或出血性并发症的危险. The treatment and prevention of thromboembolism with heparin is well recognized, but complications such as heparin cause transient thrombocytopenia, and thrombocytopenia, thought to be caused by reversible platelet aggregation, migration, May be related to heparin-induced release of adenosine diphosphate (ADP), Weismann et al reported that heparin can cause thromboembolism in 1969 was proposed heparin-induced thrombocytopenia can cause thromboembolism and was affirmed in 1973. Nearly 10 years Many reports of heparin-induced thrombocytopenia indicate a high mortality rate and the risk of thrombotic or hemorrhagic complications.