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目的观察紫杉醇(PTX)联合LFP方案治疗晚期食管癌的近期疗效及毒反应。方法46例晚期食管癌采用PTX+LFP方案,PTX按周剂量给药,即PTX80mg/m2,静脉滴注,1次/周,连续2周,LFP方案常规给药。21d为1个周期,至少完成两周期评价。结果全组46例均可评价疗效,28例初治有效率67.8%,18例复治有效率50.0%,总有效率60.8%,主要毒副作用为骨髓抑制。结论PLFP方案治疗晚期食管癌疗效较好,毒反应可以耐受,可作为治疗晚期食管癌的有效方案。
Objective To observe the short-term efficacy and toxicity of paclitaxel (PTX) combined with LFP regimen in the treatment of advanced esophageal cancer. Methods 46 cases of advanced esophageal cancer using PTX + LFP program, PTX weekly dose, namely PTX80mg / m2, intravenous infusion, 1 / week for 2 weeks, LFP regimen routine administration. 21d for a period of at least complete two-cycle evaluation. Results All the 46 cases could evaluate the curative effect, the initial effective rate of 28 cases was 67.8%, the effective rate of 18 cases was 50.0% and the total effective rate was 60.8%. The main toxic and side effects were myelosuppression. Conclusion PLFP regimen is effective in treating advanced esophageal cancer and can tolerate toxic reactions. It can be used as an effective treatment for advanced esophageal cancer.