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目的:观察心痛逐瘀汤联合氯吡格雷片对不稳定型心绞痛患者的疗效及血小板功能的影响。方法:将105例不稳定型心绞痛患者随机分为心痛逐瘀汤组、氯吡格雷片组和联合用药组,比较各组疗效和血小板功能的变化水平。结果:联合用药组在症状、心电图改善情况总有效率明显高于单独用药组,差异具有统计学意义(P<0.05)。治疗后联合用药组患者与单独用药组在血小板聚集率、TXB2和GMP-140水平差异明显,具有统计学意义(P<0.05)。结论:心痛逐瘀汤联合氯吡格雷片治疗不稳定型心绞痛疗效显著,能显著改善症状和心电图,降低血小板聚集、TXB2和GMP-140水平,具有良好应用价值,值得临床推广使用。
Objective: To observe the effects of Xintongzhuyu Decoction combined with clopidogrel on the efficacy and platelet function in patients with unstable angina pectoris. Methods: A total of 105 patients with unstable angina were randomly divided into Xintongzhuyu Decoction group, clopidogrel group and combination group. The changes of efficacy and platelet function were compared between the two groups. Results: The total effective rate of the improvement of symptoms and electrocardiogram was significantly higher in the combination group than in the single drug group (P <0.05). After treatment, there was significant difference in platelet aggregation rate, TXB2 and GMP-140 between the combination group and the drug alone group, with statistical significance (P <0.05). Conclusion: Xintongzhuyu decoction combined with clopidogrel tablets has a significant effect on unstable angina pectoris and can significantly improve the symptoms and ECG, reduce the platelet aggregation, TXB2 and GMP-140 levels, which has good application value and is worthy of clinical promotion.