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目的：探讨遗传性癫痫易感大鼠Ｐ７７ＰＭＣ听源性惊厥的神经回路。方法：Ｐ７７ＰＭＣ大鼠以标准化听刺激（１２０ｄＢ，持续６０ｓ）诱发Ⅴ级听源性惊厥，分别在惊厥后０．５、１、２、４、２４ｈ断头、取脑切片，行Ｆｏｓ免疫组化染色观察。结果：惊厥后脑内Ｆｏｓ样免疫染色强度呈明显的时间依赖和区域特点。多数核团在惊厥后０．５～１ｈ开始出现Ｆｏｓ表达，２～４ｈ达高峰，２４ｈ明显回落，不同核团其时程也存在差异，Ｆｏｓ表达最先出现在下丘平面尾侧听通道核团、中央灰质、前庭神经核，继而出现在下丘、脑桥网状结构、皮层下结构、边缘系统、额顶新皮层区、梨状皮质。脑干听通道核团及脑桥网状结构、额顶新皮层区、梨状皮质Ｆｏｓ样免疫染色最强。结论：Ｐ７７ＰＭＣ大鼠听源性惊厥可引起脑内Ｆｏｓ区域性、快速、一过性表达升高。脑干听通道、脑桥网状结构、额顶新皮层区、梨状皮质可能是其惊厥神经回路的重要组成部分
Objective: To investigate the neural circuit of auditory convulsions in P77PMC of hereditary epilepsy rats. Methods: The auditory convulsions of Grade Ⅴ were induced by standard auditory stimulus (120dB, continuous 60s) in P77PMC rats. The brain was cut off at 0.5, 1, 2, 4 and 24 hours after seizure. Fos immunohistochemistry Dyeing observation. Results: Fos-like immunostaining intensity of the brain after seizures showed obvious time-dependent and regional characteristics. Most nuclei began to show Fos expression at 0.5 ~ 1h after convulsions, peaked at 2 ~ 4h, dropped significantly after 24h, and different time courses of different nuclei also differed. Fos expression first appeared in the caudal auditory canal nucleus , Central gray matter, and vestibular nuclei, which then appear in the inferior colliculus, pontine reticular structures, subcortical structures, limbic systems, frontal cortex, and piriform cortex. Brainstem auditory canal nucleus and pontine reticular structure, frontal cortex, piriform cortex strongest Fos-like immunostaining. Conclusion: Auditory seizures in P77PMC rats can cause regional, rapid and transient expression of Fos in the brain. Brainstem auditory pathway, pontine reticular structure, frontal cortex, and piriform cortex may be important components of their convulsant neural circuits