综述了典型的固相合成法,及其在多肽、低聚核苷酸和寡糖合成中的应用。比较了固相合成法与传统的液相合成法之优缺点。介绍了固相合成法中常用的高分子载体;氨基、羧基、羟基、磷酸基等功能基的化学保护方法。介绍了1984年诺贝尔奖金获得者,固相合成创始人R.B.Merrifield在此领域中的成就。引用了1963～1986年的60篇文献。 A review of the typical solid-phase synthesis and its application in the synthesis of peptides, oligonucleotides and oligosaccharides are presented. The advantages and disadvantages of solid-phase synthesis and traditional liquid-phase synthesis were compared. Introduced the solid phase synthesis of commonly used polymer carrier; amino, carboxyl, hydroxyl, phosphate and other functional chemical protection methods. The achievements of R.B. Merrifield, the founder of solid phase synthesis, who won the Nobel Prize in 1984, are introduced in this field. Cited 60 articles from 1963 to 1986.