论文部分内容阅读
目的：研究血清褪黑素与十二指肠溃疡（ＤＵ）发生的关系。方法：用酶联法测定ＤＵ患者血清４ Ａｍ褪黑素，取正常参照组做比较。并比较急性期和疤痕期，ＨＰ阴性和阳性血清褪黑素浓度变化。结果：ＤＵ组血清褪黑素比正常参照组低（Ｐ＜０．０５），分别为５０．３８±１３．３４和７７．７３±２８．４１ｎｇ／Ｌ。ＤＵ患者急性期比疤痕期低（Ｐ＜０．０５），分别为４４．０８±１２．０２和５８．０３±１０．８７ ｎｇ／Ｌ。ＨＰ阴性ＤＵ患者比ＨＰ阳性低（Ｐ＜０．０５），分别为４３．５２±７．８ ｎｇ／Ｌ和６５．４２±１１．１０ ｎｇ／Ｌ。结论：血清褪黑素水平降低可能是十二指肠溃疡发生的机制之一。
Objective: To study the relationship between serum melatonin and duodenal ulcer (DU). Methods: Serum 4-Am melatonin was detected by enzyme-linked immunosorbent assay (ELISA) and compared with normal control group. The changes of serum concentrations of melatonin, HP-negative and positive were compared between acute and scarring. Results: The levels of melatonin in DU group were lower than those in normal control group (P <0.05), which were 50.38 ± 13.34 and 77.73 ± 28.41 ng / L, respectively. The acute phase of DU patients was lower than the scar (P <0.05), 44.08 ± 12.02 and 58.03 ± 10.87 ng / L, respectively. Patients with HP-negative DU had a lower positive (P <0.05) HP than those with HP, 43.52 ± 7.8 ng / L and 65.42 ± 11.10 ng / L, respectively. Conclusion: The decrease of serum melatonin may be one of the mechanisms of duodenal ulcer.