目的 :了解辛伐他汀对血浆C反应蛋白 (CRP)的影响。方法 :90例高脂血症患者随机分为治疗组4 5例 (口服辛伐他汀 2 0mgqn× 1个月 )和对照组 4 5例 (饮食和生活方式调整 ,未服用调脂药物 ) ,治疗前后分别测定血浆总胆固醇 (TC)、三酰甘油 (TG)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)和高敏感CRP(hsCRP)。结果 :1个月后治疗组TC、LDL C分别降低了 2 0 .8%和 2 1.4 % ,HDL C升高了 6 .3% ,hsCRP降低了 7.6 % ,hsCRP的变化与HDL C的变化呈负相关。对照组上述指标均无明显变化。结论 :辛伐他汀不仅可以调节血脂代谢的失衡 ,而且可以降低血浆CRP水平 ,CRP的降低独立于LDL C的降低 ,但与HDL C的升高相关。 Objective: To understand the effect of simvastatin on plasma C-reactive protein (CRP). Methods: Totally 90 patients with hyperlipidemia were randomly divided into treatment group 45 cases (simvastatin 20 mg qn x 1 month) and control group 45 cases (diet and lifestyle adjustment, not taking lipid-lowering drugs), treatment Plasma total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL C), low density lipoprotein cholesterol (LDL C) and high sensitive CRP (hsCRP) were measured before and after treatment. Results: TC and LDL C decreased by 20.8% and 21.4%, HDL C increased by 6.3%, and hsCRP decreased by 7.6% after 1 month. The changes of hsCRP and HDL C were significantly Negative correlation. There was no significant change in the above indicators in the control group. Conclusion: Simvastatin can not only regulate the imbalance of blood lipid metabolism, but also reduce the level of plasma CRP. The decrease of CRP is independent of the decrease of LDL C, but is related to the increase of HDL C.