目的 :探讨严重急性呼吸综合征相关冠状病毒 (SARS- Co V)对心肌组织损害的发生规律。 方法 :将 2 4例患者按病程长短分为 组 (病程 <14 d,n=16 )和 组 (病程≥ 14 d,n=8) ,观察其心肌酶谱的变化及其他相关体征。 结果 : 组4 3.8% (7/16 )的患者血清肌酸激酶同工酶 (CK- MB) >10 0 IU/L,5 6 .2 % (9/16 )的患者乳酸脱氢酶 (L DH- 1) >16 0 IU/L,明显高于 组的 0 (0 /8)、2 5 % (2 /8) (P<0 .0 5 ) ; 组患者胸闷、心悸和肌肉酸痛发生率分别为 4 3.8%、37.5 %、5 0 .0 % ,明显高于 组的 2 5 .0 %、12 .5 %、37.5 % (P<0 .0 5 ) ;心率普遍较快 , 组为 80～ 10 5 (90 .4± 8.1)次 /min, 组为 72～ 87(81.9± 4 .9)次 /min。结论 :SARS- Co V对心肌组织的损害可能发生于发病后 2周内 ,早期密切观察心肌酶谱及相关体征的变化 ,尽早进行干预性治疗对预防心血管并发症的发生具有重要意义 Objective: To investigate the occurrence of myocardial damage caused by severe coronavirus (SARS-Co V) associated with acute respiratory syndrome. Methods: Twenty-four patients were divided into groups (duration <14 days, n = 16) and groups (duration 14 days, n = 8) according to their duration of disease. Changes of myocardial enzymes and other related signs were observed. RESULTS: In group 4, 3.8% (7/16) of patients had serum creatine kinase (CK-MB)> 10 0 IU / L and 56.2% (9/16) of patients had lactate dehydrogenase DH 1)> 16 0 IU / L was significantly higher than 0 (0/8), 25% (2/8) (P <0. 05) of the group. The incidence of chest tightness, palpitations and muscle sore (3.8%, 37.5% and 50.0%, respectively), which were significantly higher than those of 25.0%, 12.5% ​​and 37.5% (P <0.05) ~ 105 (90.4 ± 8.1) times / min, the group was 72 ~ 87 (81.9 ± 4.9) times / min. CONCLUSIONS: SARS-Co V damage to myocardium may occur within 2 weeks after onset, and early observation of myocardial enzymes and related signs of change, early intervention in the prevention of cardiovascular complications is of great significance