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[目的]探讨阿托伐他汀对高血压患者肾损害的影响。[方法]选取血压控制达标的高血压并微量白蛋白尿患者100例,随机分为治疗组和对照组,治疗组予以阿托伐他汀20mg/d,对照组加用安慰剂治疗,两组治疗前及治疗后12周采用速率散射比浊法检测尿微量白蛋白(mAlb)、β2-微球蛋白(β2-MG),全定量酶免疫法测定尿视黄醇结合蛋白(RBP),速率法检测N-乙酰-β-D氨基葡萄糖苷酶(NAG),Jaffe速率法测定尿肌酐。[结果]治疗组患者RBP、mAlb、β2-MG、NAG均较治疗前和对照组治疗后显著下降,差异均有高度统计学意义(均P﹤0.01),无严重不良反应。[结论]阿托伐他汀能减轻高血压患者肾损害及改善肾功能。
[Objective] To investigate the effect of atorvastatin on renal damage in hypertensive patients. [Methods] A total of 100 patients with hypertension and microalbuminuria who achieved blood pressure control were randomly divided into treatment group and control group. Atorvastatin 20 mg / d and placebo were given to the control group. The two groups were treated Urine microalbumin (mAb), β2-microglobulin (β2-MG) and urinary retinol binding protein (RBP) were measured before and 12 weeks after treatment by rate nephelometry, N-acetyl-β-D-glucosaminidase (NAG) was detected and urinary creatinine was measured by the Jaffe method. [Results] The RBP, mAlb, β2-MG and NAG in the treatment group were significantly lower than those before treatment and in the control group after treatment, the differences were highly statistically significant (all P <0.01), no serious adverse reactions. [Conclusion] Atorvastatin can reduce renal damage and improve renal function in hypertensive patients.