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运动和高血压心肌肥大的细胞表型改变明显不同，心肌局部血管紧张素Ⅱ（ＡｎｇⅡ）参与运动和高血压心肌肥大形成。为了解心肌局部ＡｎｇⅡ是否参与两种不同心肌肥大细胞表型变化调节，本实验对正常和自发性高血压大鼠（ＳＨＲ）运动后心肌ＡｎｇⅡ与肌球蛋白重链（ＭＨＣ）异型变化进行相关分析，结果表明正常安静大鼠心肌ＡｎｇⅡ与ａ－和β－ＭＨＣ变化无明显相关性（ｒ＝０．１７４７：０．１７３２，Ｐ＞０．０５），但经过１２周游泳训练运动后，心肌ａ－ＭＨＣ增加，ＡｎｇⅡ含量升高，两者呈正相关（ｒ＝０．７７２３，Ｐ＜０．０５）。ＳＨＲ心肌ＡｎｇⅡ和β－ＭＨＣ比ＷＫＹ高８８．０２％和４６．８９％，两者呈正相关（ｒ＝０．８７０５，Ｐ＜０．０５），ＳＨＲ心肌ＡｎｇⅡ与ａ－ＭＨＣ呈负相关（ｒ＝－０．８６２２，Ｐ＜０．０５），ＷＫＹ心肌ＡｎｇⅡ与ａ－和β－ＭＨＣ之间无明显相关性（ｒ＝０．２９３５；０．０２６３，Ｐ＞０．０５）。ＳＨＲ经１０周游泳运动后，心肌ＡｎｇⅡ含量下降，β－ＭＨＣ向ａ－ＭＨＣ逆转，ＡｎｇⅡ与ａ－／β－ＭＨＣ呈正相关（ｒ＝０．７９３４：Ｐ＜０．０５）。以上结果提示心肌局部ＡｎｇⅡ在运动性心肌肥大中可能具有对ａ－ＭＨＣ表达上调作用?
The cell phenotypes of exercise and hypertensive cardiac hypertrophy were significantly different. Angiotensin Ⅱ (Ang Ⅱ) was involved in exercise and hypertensive cardiac hypertrophy. In order to understand whether myocardial AngⅡ is involved in the regulation of phenotype changes in two different cardiac myocytes, the correlation between myocardial Ang Ⅱ and myosin heavy chain (MHC) abnormalities in normal and spontaneously hypertensive rats (SHR) (R = 0.1747: 0.1732, P> 0.05). However, after a 12-week swimming training exercise, the changes of myocardial a -MHC increased, AngⅡ increased, the two were positively correlated (r = 0.7723, P <0.05). The levels of Ang Ⅱ and β-MHC in SHR were 88.02% and 46.89% higher than those in WKY, respectively (r = 0.8705, P <0.05) = -0.8622, P <0.05). There was no significant correlation between Ang Ⅱ and a- and β-MHC in WKY myocardium (r = 0.2935; 0.0263, P> 0.05). After 10-week swimming exercise, the content of AngⅡ in myocardium decreased, while β-MHC reversed a-MHC. There was a positive correlation between AngⅡ and a- / β-MHC (r = 0.7934: P <0.05). The above results suggest that myocardial AngⅡ may up-regulate the expression of a-MHC in exercise-induced cardiac hypertrophy.