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目的:研究芍药苷对附子中双酯型生物碱体内蓄积的影响。方法:大鼠分别灌胃乌头碱、新乌头碱、次乌头碱以及这3种乌头碱分别与芍药苷的混合物,采用LC-MS分别测定乌头碱、新乌头碱、次乌头碱3种生物碱在大鼠心、肝和肾脏组织中的含量,并比较与芍药苷配伍前后乌头碱、新乌头碱、次乌头碱3种生物碱在组织中的含量变化。结果:与芍药苷配伍后,乌头碱和次乌头碱在心脏组织中的蓄积量减少,新乌头碱配伍芍药苷后,在心、肝和肾脏组织中的蓄积量均减少。结论:与芍药苷配伍,能减少附子中3种双酯型生物碱的在心、肝、肾等脏器的蓄积,从而降低附子双酯型生物碱的毒性,尤其是对心脏的毒性,这可能是附子、白芍配伍减毒的机制之一。
Objective: To study the effect of paeoniflorin on the accumulation of diacyl alkaloids in aconite. Methods: Aconitine, mesaconitine, hypaconitine and mixtures of paeoniflorin and aconitine were respectively administered to rats, and aconitine, mesaconitine, Contents of three alkaloids of aconitine in rat heart, liver and kidney tissues, and the content changes of aconitine, mesaconitine and hypaconitine alkaloids before and after compatibility with paeoniflorin . Results: When aconitine and paeoniflorin were combined, the accumulation of aconitine and hypaconitine in heart tissue decreased. After the addition of mesaconine and paeoniflorin, the accumulation in heart, liver and kidney decreased. CONCLUSION: The combination with paeoniflorin can reduce the accumulation of the three diester alkaloids in the heart, liver and kidney, and thus reduce the toxicity of the aconite dimer alkaloids, especially to the heart, which may be Is aconite, white peony compatibility of one of the mechanisms of attenuation.