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目的研究孕妇产前糖化血红蛋白水平对妊娠结局的影响及体重指数与产前糖化血红蛋白水平的相关性。方法对79例妊娠期糖尿病患者强化健康宣教和血糖控制,并根据产前糖化血红蛋白水平不同比较妊娠结局。结果产前糖化血红蛋白水平与孕妇产前体重指数成正比。产前糖化血红蛋白水平≤6%的妊娠期糖尿病患者,其妊娠期高血压疾病、羊水过多、胎膜早破发生率低于产前糖化血红蛋白水平>6%的患者(P<0.05)。且早产儿、新生儿窒息的发生率亦明显减低(P<0.05)。产前糖化血红蛋白水平>6%的患者体重指数与产前糖化血红蛋白水平成正比(R2=0.1412,P<0.05),产前糖化血红蛋白水平≤6%的妊娠期糖尿病患者及正常妊娠者体重指数与糖化血红蛋白水平无明显相关性。结论加强血糖和体重控制,可明显降低妊娠期糖尿病母婴并发症发生率。
Objective To study the effect of prenatal glycosylated hemoglobin (HbAb) level on pregnancy outcomes and the relationship between body mass index and pre-natal HbA1c level. Methods 79 cases of gestational diabetes patients with health education and blood glucose control, and according to the different levels of prenatal glycosylated hemoglobin pregnancy outcome. Results Prenatal HbA1c was directly proportional to prenatal body mass index. Patients with gestational diabetes with prenatal glycosylated hemoglobin level ≤6% had gestational hypertension, polyhydramnios, and premature rupture of membranes with a rate of> 6% compared with those with prenatal glycosylated hemoglobin (P <0.05). And the incidence of premature infant and neonatal asphyxia was also significantly reduced (P <0.05). BMI was positively correlated with prenatal glycosylated hemoglobin (R2 = 0.1412, P <0.05) in patients with prenatal glycosylated hemoglobin level> 6%. The body mass index of gestational diabetes mellitus and normal pregnancy with prenatal glycosylated hemoglobin level <6% Glycosylated hemoglobin level no significant correlation. Conclusions Strengthening blood glucose and weight control can significantly reduce the incidence of maternal and neonatal complications of gestational diabetes mellitus.