肺癌是常见八大恶性肿瘤之一,发病率逐年上升,临床表现复杂,诊断后的患者大部分已失去手术机会,预后差,发病率死亡率几乎平行。究其原因,缺乏科学合适的动物模型是对肺癌研究落后的原因之一,因此模拟出与人类肺癌病因、发病机制、发展过程及治疗相似的动物模型是需要迫切解决的 Lung cancer is one of the common malignant neoplasms. The incidence is increasing year by year. The clinical manifestations are complex. Most of the patients after diagnosis have lost the chance of surgery. The prognosis is poor and the morbidity and mortality are almost parallel. The reason, the lack of a scientific animal model of lung cancer is one of the reasons behind, so to simulate and human lung cancer etiology, pathogenesis, development and treatment of animal models that need to be urgently addressed