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抗磷脂抗体(APA)是一类获得性自身抗体,通常以心脂素(cardiolipin)作抗原,用固相免疫分析法来检测它。已知它常见于结缔组织疾病等有关疾病中。风湿性多肌痛(PMR)和巨细胞动脉炎(GCA)是常一起发生的病变。内皮细胞损害是 GCA 的一种常见特征,而动脉闭塞则是这种血管病变的严重并发症。考虑到有 APA 的病人亦表现有血管闭塞,故作者认为这些抗体可能在 GCA 的发病机理中起重要作用。为此,作者对一组伴有或不伴有活检证实为GCA 的 PMR 病人,测定其抗心脂索抗体(aCL)的阳性率,以了解其与血管并发症的关系。病人和方法共50例病人(女34人,男16人),其中30例为 PMR,另20例为 PMR/GCA。PMR 组平均年龄为71.2岁,PMR/GCA 组为72.4岁;两组的男女比分别为9:21和7:13。PMR 的诊断符合由
Antiphospholipid antibodies (APA) are a class of acquired autoantibodies that are usually detected by solid phase immunoassay using cardiolipin as an antigen. It is known to be common in connective tissue diseases and other related diseases. Rheumatic polymyalgia (PMR) and giant cell arteritis (GCA) are frequently associated lesions. Endothelial cell damage is a common feature of GCA, and arterial occlusion is a serious complication of this vascular lesion. Given that patients with APA also exhibit vascular occlusion, the authors believe these antibodies may play an important role in the pathogenesis of GCA. To this end, the authors of a group of PMR patients with or without biopsy confirmed GCA, the determination of the positive rate of anti-cardiolipin antibodies (aCL), to understand its relationship with vascular complications. Patients and Methods A total of 50 patients (34 women, 16 males), of which 30 were PMR and the other 20 were PMR / GCA. The average age of the PMR group was 71.2 years and that of the PMR / GCA group was 72.4 years. The male-female ratio of the two groups was 9:21 and 7:13, respectively. PMR diagnosis is consistent with