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目的研究新发现的基因内质网膜复合亚基6(EMC6)在正常宫颈、宫颈上皮内瘤样病变及宫颈癌组织中的表达。方法收集正常宫颈组织(正常宫颈组)及宫颈上皮内瘤变组织(CIN组)各80例和宫颈癌组织100例(宫颈癌组)石蜡组织标本。用免疫组化法研究EMC6分别在上述病例中的表达。结果宫颈癌组中EMC6表达率为64.0%(64/100),CIN组中EMC6表达率为93.8%(75/80),正常宫颈组中EMC6表达率为81.3%(65/80),各组EMC6表达差异有统计学意义(P<0.05)。EMC6蛋白表达率与宫颈癌患者年龄、临床分期、癌组织的大小、大体类型、病理类型、分化程度、有无淋巴结转移等均无相关性(P>0.05)。结论 EMC6的表达降低可能参与了宫颈癌的发生、发展。但EMC6表达水平与宫颈癌患者的各临床特征,包括年龄、期别、癌组织的大小、大体类型、病理类型、病理分化程度、有无淋巴结转移等无关。
Objective To study the expression of newly discovered gene endoplasmic reticulum membrane subunit 6 (EMC6) in normal cervical and cervical intraepithelial neoplasia and cervical cancer. Methods 80 cases of normal cervical tissue (normal cervical group) and cervical intraepithelial neoplasia (CIN group) and 100 cases of cervical cancer tissue (cervical cancer group) were collected. Immunohistochemistry was used to study the expression of EMC6 in the above cases. Results The positive rate of EMC6 in cervical cancer group was 64.0% (64/100), the positive rate of EMC6 in CIN group was 93.8% (75/80), and the positive rate of EMC6 in normal cervical group was 81.3% (65/80) EMC6 expression difference was statistically significant (P <0.05). There was no correlation between the expression of EMC6 protein and the age, clinical stage, size of cancer, gross type, pathological type, degree of differentiation and lymph node metastasis of cervical cancer (P> 0.05). Conclusion The decreased expression of EMC6 may be involved in the occurrence and development of cervical cancer. However, the expression level of EMC6 is not associated with the clinical features of patients with cervical cancer, including age, stage, size of cancer, general type, pathological type, pathological differentiation and lymph node metastasis.