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目的探讨甲状腺功能亢进症(甲亢)眼病大剂量糖皮质激素冲击加免疫抑制剂治疗的临床效果。方法 96例甲亢眼病患者,随机分为A组(糖皮质激素口服)、B组(大剂量糖皮质激素冲击治疗)、C组(大剂量糖皮质激素冲击联合免疫抑制剂治疗),各32例。对比三组患者的临床治疗效果。结果治疗6个月后,C组治疗总有效率为90.6%(29/32),明显高于A、B组的56.3%(18/32)、62.5%(20/32),差异有统计学意义(P<0.05)。A、B、C组不良反应发生率分别为65.6%(21/32)、25.0%(8/32)、21.9%(7/32),A组不良反应发生率高于B、C组,差异有统计学意义(P<0.05);B组与C组不良反应发生率比较,差异无统计学意义(P>0.05)。结论大剂量糖皮质激素冲击加免疫抑制剂治疗甲亢眼病临床效果良好,不良反应发生率低,安全性高,值得临床推广应用。
Objective To investigate the clinical effect of high dose glucocorticoid shock plus immunosuppressive therapy on hyperthyroidism (hyperthyroidism) eye disease. Methods A total of 96 patients with hyperthyroidism were randomly divided into group A (glucocorticoid orally), group B (high dose glucocorticoid shock treatment), group C (high dose glucocorticoid shock combined with immunosuppressive agents) and 32 patients . Compare the clinical effect of three groups of patients. Results After 6 months of treatment, the total effective rate in group C was 90.6% (29/32), significantly higher than 56.3% (18/32) and 62.5% (20/32) in group A and group B, respectively, and the difference was statistically significant Significance (P <0.05). The adverse reactions in group A, B and C were 65.6% (21/32), 25.0% (8/32) and 21.9% (7/32), respectively. The incidence of adverse reactions in group A was higher than that in group B and C (P <0.05). There was no significant difference in adverse reactions between group B and group C (P> 0.05). Conclusion High-dose glucocorticoid shock plus immunosuppressive agents have a good clinical effect in the treatment of hyperthyroidism and eye diseases. The incidence of adverse reactions is low and the safety is high. It is worthy of clinical application.