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左氧氟沙星可干扰中枢γ-氨基丁酸(GABA)的功能,引起失眠或某些精神异常现象。注意利用该药是由肾脏以原形排泄的性质,通过加强尿路排泄以降低血药浓度水平,是规避与减轻左氧氟沙星精神系统不良反应值得重视的措施。尽早给药可避免或减轻夜间睡眠障碍,个别意识丧失患者可予以导尿处置;非甾体抗炎药物(NSAIDs)可增强左氧氟沙星对中枢γ-氨基丁酸(GABA)功能的干扰而诱发精神症状,应避免合用;左氧氟沙星诱发的低血糖反应与心脏功能障碍也可出现精神系统不良反应症状,应注意识别与合理处置。
Levofloxacin can interfere with central gamma-aminobutyric acid (GABA) function, causing insomnia or some mental abnormalities. Note that the use of the drug is excreted by the kidney as the nature of the nature, by enhancing urinary tract excretion to reduce blood levels, is to avoid and alleviate the adverse reactions of levofloxacin system should pay attention to measures. Early administration can prevent or reduce nocturnal sleep disorders, and some patients with unconsciousness may be given catheterization. Non-steroidal anti-inflammatory drugs (NSAIDs) may enhance the interference of central levofloxacin on GABA function and induce psychiatric symptoms , Should be avoided; levofloxacin-induced hypoglycemia and cardiac dysfunction may also appear adverse symptoms of mental disorders, attention should be paid to identify and reasonable disposal.