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应用组织化学和生物化学的方法观察出生前、后发育中大鼠肾和空肠γ-谷氨酰转肽酶(γ-GT)的变化。肾γ-GT活性随着大鼠年龄的增长而逐渐升高。胎鼠后肾γ-GT主要位于肾小管腔面;生后大鼠肾γ-GT除了位于近曲小管上皮刷状缘和髓袢上皮之外,还发现在近曲小管上皮的基底部,肾皮质和髓质中微血管壁也有γ-GT活性。而且在肾皮质深层γ-GT活性明显高于皮质浅层。 胎鼠空肠仅仅在小肠绒毛形成之后,上皮细胞才有较明显的γ-GT活性。胎龄21天活性最高,出生后下降。
The histochemical and biochemical methods were used to observe the changes of γ-glutamyl transpeptidase (γ-GT) in the kidney and jejunum of prenatal and postnatal rats. The renal γ-GT activity gradually increased with the age of rats. The fetal rat renal γ-GT is mainly located in the renal tubular surface; after birth, rat renal γ-GT in addition to the proximal tubule epithelial brush border and medullary epithelium, also found in the proximal tubule epithelial base, Microvascular walls in the renal cortex and medulla also have γ-GT activity. And in the deep renal cortex γ-GT activity was significantly higher than the cortical superficial. Fetal rat jejunal mesenteric villus only after epithelial cells have more obvious γ-GT activity. 21 days gestational age the highest activity, decreased after birth.