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目的:应用血管内超声(IVUS)和冠状动脉造影(CAG)研究冠状动脉斑块特征与C-反应蛋白(CRP)水平的联系。方法:成功接受CAG和IVUS检查并诊断为单支冠状动脉病变的不稳定型心绞痛患者41例,经检测血清CRP并按CRP水平分为高CRP组(CRP≥3 mg/L)和正常CRP组(CRP<3 mg/L),比较2组间的斑块特征。结果:2组患者病变狭窄程度、斑块面积、长度正性重构及偏心斑块等差异无统计学意义(均P>0.05),但高CRP组与低CRP组比较,低回声斑块、薄纤维帽斑块显著增多(均P<0.05)。结论:CRP水平升高和低回声斑块、薄纤维帽斑块有关。
OBJECTIVE: To investigate the relationship between coronary plaque characteristics and C-reactive protein (CRP) levels by means of intravascular ultrasound (IVUS) and coronary angiography (CAG). Methods: Thirty-one patients with unstable angina pectoris who underwent CAG and IVUS examinations and were diagnosed as single coronary artery disease were enrolled. Serum CRP level was measured and divided into high CRP group (CRP≥3 mg / L) and normal CRP group according to CRP level (CRP <3 mg / L), the plaque characteristics were compared between the two groups. Results: There was no significant difference in stenosis degree, plaque area, positive length remodeling and eccentric plaque in the two groups (all P> 0.05). However, in the high CRP group and the low CRP group, the hypoechoic plaque, Thin fibrous cap plaques increased significantly (both P <0.05). CONCLUSION: Elevated CRP is associated with hypoechoic plaque and thin fibrous cap plaques.