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目的:基于临床数据统计丹红注射液常见临床联用药物,并针对联用组合进行药物相互作用文献研究,为进一步开展药物相互作用实验评价,完善联合用药方案奠定基础。方法:采用回顾性研究方法,基于南京中医药大学附属医院信息系统(HIS)选取2014年1月-12月使用丹红注射液的2673例患者医嘱信息,运用基本统计和关联分析方法整理联合用药信息,并针对联用频率排序前5位的药物组合,通过CNKI、Pubmed、Web of Science与Cochrane Library检索2000年1月-2016年1月的药物相互作用文献进行研究。结果:丹红注射液临床常与抗血小板药、调血脂药和脑血管病药物联用,单项合并用药联用频次排序前5为阿司匹林、氯吡格雷、阿托伐他汀、瑞舒伐他汀和美托洛尔。多项关联分析置信度最高为丹红注射液+氯吡格雷+阿托伐他汀,其次为丹红注射液+阿司匹林+阿托伐他汀。文献检索发现丹红注射液与这些药物联用的临床效益较好,但仍潜在风险。结论:丹红注射液联合用药复杂,常与功效相近的西药联用,且文献研究表明联合用药研究以协同增效为主,为保证临床用药安全和效益,需进行系统的药物相互作用实验研究,完善联合用药方案,为中药注射剂联合用药提供示范性研究。
OBJECTIVE: Based on the clinical data, the commonly used clinical drugs of Danhong injection were statistically analyzed in the literature of drug interactions for the combination therapy, so as to lay the foundation for further experimental evaluation of drug interactions and perfection of the combination drug regimen. Methods: A retrospective study was conducted to determine the medical orders of 2673 patients using Danhong injection from January 2014 to December 2014 based on the information system (HIS) of Nanjing University of Chinese Medicine Affiliated Hospital, and the basic statistics and correlation analysis were used to sort out the combination therapy Information, and the top 5 drug combinations for the combination frequency were studied by CNKI, Pubmed, Web of Science and the Cochrane Library from January 2000 to January 2016 drug interaction literature. Results: Danhong injection often combined with antiplatelet drugs, lipid-lowering drugs and cerebrovascular disease drugs, the single combined combination of medication frequency top 5 aspirin, clopidogrel, atorvastatin, rosuvastatin and the United States Tollor. A number of correlation analysis of the highest confidence Danhong injection + clopidogrel + atorvastatin, followed by Danhong injection + aspirin + atorvastatin. The literature search found that Danhong injection combined with these drugs has good clinical benefit, but it still has the potential risk. Conclusion: Danhong injection combined with medication is complex, often associated with similar efficacy of western medicine, and literature studies show that the synergistic combination of drug-based study, in order to ensure the safety and effectiveness of clinical medication, the need for systematic study of drug interactions , Improve the combination of drug programs for the Chinese medicine injection to provide a demonstration study.