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内皮Per Arnt Sim结构域蛋白1(EPAS1)在缺氧条件下被诱导产生,它能够激活一些与血管生成、能量代谢相关的基因。EPAS1在肿瘤相关巨噬细胞(TAMs)中的表达在肿瘤进程中扮演多重角色,可能对膀胱癌的进展有促进作用。作者对6 9例经根治性膀胱切除术后的T1～4N0～2 M0 期高分级的膀
Endothelial Per Arnt Sim domain protein 1 (EPAS1) is induced under hypoxic conditions and activates a number of genes involved in angiogenesis and energy metabolism. The expression of EPAS1 in tumor-associated macrophages (TAMs) plays a multi-role in tumor progression and may promote the progression of bladder cancer. The authors of 69 cases of radical cystectomy after T1 ~ 4N0 ~ 2 M0 high-grade bladder